Genetics
Statins should benefit CETP TaqIB B1B1 carriers most, since they have the highest baseline CETP activity (J Atheroscler Thromb 2002)
Original title: Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: comparison among CETP/TaqIB genotype subgroups
In 30 Japanese hypercholesterolemic patients stratified by CETP TaqIB genotype, plasma CETP activity (158 +/- 23% of control) and concentration (4.1 +/- 1.0 mg/l) were significantly higher in B1B1 than B2B2 subjects (106 +/- 25% and 2.5 +/- 1.1 mg/l, P<0.005), with B1B2 intermediate and significantly lower than B1B1 (P<0.05). Both CETP activity and concentration correlated positively with LDL-cholesterol (r=0.608, P<0.0005 and r=0.552, P<0.005). Statin treatment significantly reduced both CETP activity (P<0.01) and concentration (P<0.05). The authors conclude statins should be particularly effective at raising HDL in Japanese B1B1 carriers, who have lower baseline HDL-cholesterol and higher CETP than other genotypes, suggesting CETP genotype may help tailor treatment.
Original abstract
We investigated the effects of HMG-CoA reductase inhibitors (statins) on the activity and concentration of plasma cholesterol ester transfer protein (CETP) in 30 hypercholesterolemic patients. Patients were divided into three groups according to TaqIB polymorphism of the CETP gene. The activity (158 +/- 23% control, mean +/- SEM) and concentration (4.1 +/- 1.0 mg/l) of plasma CETP were significantly (p < 0.005) higher in the subjects with the B1B1 genotype than B2B2 genotype (106 +/- 25% and 2.5 +/- 1.1 mg/l, respectively). Plasma CETP activity and concentration levels in the B1B2 group were intermediate between those of the B1B1 and B2B2 groups, and significantly (p < 0.05) low compared with the B1B1 group.Both the activity and concentration of plasma CETP were positively correlated with the LDL-cholesterol concentration (r = 0.608, p < 0.0005 and r = 0.552, p < 0.005, respectively). The administration of statins significantly reduced not only the activity (p < 0.01) but also the concentration (p < 0.05) of plasma CETP in hypercholesterolemic patients. Taken together, we confirmed that statins would be effective in increasing HDL levels in Japanese B1B1 carriers, because of a lower concentration of HDL cholesterol and higher level of plasma CETP compared to the other genotypes. The genetic variation in the CETP gene may be one important factor in designing better treatments.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.