Genetics
CETP TaqI B1B2 genotype triples hypertension risk in North Indian diabetics despite no direct T2DM link (BMC Endocr Disord 2005)
Original title: Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study
In 136 North Indian patients with type II diabetes and 264 healthy controls, CETP TaqI B, D442G, and APOE HhaI polymorphisms were tested for association with diabetes and its complications. CETP TaqI B polymorphism was not associated with T2DM itself, and the D442G mutation was absent in this population, but the CETP B1B2 genotype was significantly associated with a higher risk of hypertension among diabetic patients (OR=3.068, 95% CI 1.183-7.958, p=0.028). Diabetic patients with neuropathy or retinopathy had significantly different total and LDL-cholesterol levels than patients with uncomplicated T2DM, but these lipid differences did not correlate with CETP or APOE genotype. CETP TaqI B polymorphism may thus contribute to hypertension risk in T2DM without directly predisposing to diabetes itself.
Original abstract
Background: Genetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with type II diabetes mellitus (T2DM). Goal of the present study was to determine the association of cholesteryl ester transfer protein TaqI B, D442G, and APOE Hha I polymorphisms with T2DM and its complications.
Methods: Study subjects were 136 patients and 264 healthy controls. All polymorphisms were detected using PCR-RFLP and statistical analysis done with chi2 test and ANOVA.
Results: Although CETP TaqI B polymorphism was not associated with the T2DM, yet B1B2 genotype was significantly (p = 0.028) associated with high risk of hypertension in diabetic patients (OR = 3.068, 95% CI 1.183-7.958). In North Indians D442G variation in CETP gene was found to be absent. Frequency of APOE HhaI polymorphism was also not different between patients and controls. In diabetic patients having neuropathy and retinopathy significantly different levels of total-cholesterol [(p = 0.001) and (p = 0.029) respectively] and LDL-cholesterol [(p = 0.001) and (p = 0.001) respectively] were observed when compared to patients with T2DM only. However, lipid levels did not show any correlation with the CETP TaqI B and APOE Hha I genetic polymorphisms.
Conclusion: CETP TaqI B and APOE HhaI polymorphism may not be associated with type II diabetes mellitus in North Indian population, however CETP TaqI B polymorphism may be associated with hypertension along with T2DM.
blood pressurediabetesgenetics
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.