Genetics
CETP TaqIB and LPL Ser447Ter polymorphisms show no association with ischaemic stroke in Greek patients (Neurosci Lett 2005)
Original title: Cholesteryl ester transfer protein TaqI B and lipoprotein lipase Ser447Ter gene polymorphisms are not associated with ischaemic stroke in Greek patients
Researchers examined the CETP TaqI B and lipoprotein lipase (LPL) Ser447Ter polymorphisms in 98 Greek patients with clinically diagnosed late-onset ischaemic stroke and 100 ethnicity-, age-, and sex-matched controls without vascular disease, to test whether genetically altered CETP or LPL activity affects stroke susceptibility. Analyzed separately or in combination, neither polymorphism showed a statistically significant difference in distribution between stroke patients and controls. The authors conclude CETP TaqI B and LPL Ser447Ter polymorphisms are not associated with ischaemic stroke risk in this Greek population.
Original abstract
Cholesteryl ester transfer protein (CETP) and lipoprotein lipase (LPL) are both key players in plasma lipoprotein homeostasis and, as such, genetically induced alterations in their respective activities may affect susceptibility to cerebrovascular diseases. In this study, we examined the distribution of two common polymorphisms, namely CETP TaqI B and LPL Ser447Ter in a cohort of Greek clinically diagnosed late-onset ischaemic stroke patients (n = 98) and an ethnicity-, age- and sex-matched control group with no manifestations of vascular disease (n = 100). Our study revealed no statistically significant differences with respect to the distribution of either polymorphism, examined separately or in combination, between the two groups.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.