Genetics
CETP D442G mutation raises HDL cholesterol in Vietnamese schoolgirls regardless of nutritional status (Pediatr Res 2005)
Original title: Effect of the cholesteryl ester transfer protein genotypes on plasma lipid and lipoprotein levels in Vietnamese children
In 348 Vietnamese girls aged 7-9 with varying nutritional status, CETP I14A, D442G, and TaqIB genotypes were identified by Invader assay. The D442G mutation, present at a frequency of 0.034 (I14A was absent), was associated with significantly higher HDL-cholesterol than in noncarriers regardless of nutritional status, though LDL-cholesterol and triglyceride were not significantly lower in carriers. The TaqIB2 allele frequency was 0.34, lower than reported in other Asian populations, and TaqIB2B2 carriers also had significantly higher HDL-cholesterol, though this association was weaker than for D442G. CETP genetic variation may therefore account for a substantial share of HDL-cholesterol variation in Vietnamese children.
Original abstract
Cholesteryl ester transfer protein (CETP) is understood to play a regulatory role in HDL cholesterol (HDLC) metabolism. In this study, the effect of CETP genotypes on plasma lipid and lipoprotein levels in 348 Vietnamese girls (aged 7-9) with different nutritional conditions was analyzed. The two mutations, intron 14 G(+1)-to-A (I14A) and Asp 442 to Gly within exon 15 (D442G), and the TaqIB polymorphism in the CETP gene were identified by an Invader assay. The D442G mutation was present with a frequency of 0.034, while the I14A mutation was absent. HDLC levels were significantly higher in carriers of the D442G mutation than in noncarriers, regardless of the nutritional status. Low-density lipoprotein (LDL) cholesterol and triglyceride levels were not significantly lower in carriers of D442G mutation. The frequency of the TaqIB2 allele was 0.34, which was lower than that observed in other Asian populations. TaqIB2B2 carriers also had significantly higher HDLC levels, but this association was weaker than that of the D442G mutation. Overall, genetic variations at the CETP gene locus may account for a significant proportion of HDLC variation in Vietnamese children.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.