Genetics
CETP Taq1B B1 allele linked to worse lipid profile and higher blood pressure in kidney transplant patients (Transplant Proc 2006)
Original title: Effects of cholesteryl ester transfer protein TAQ1B polymorphism in renal transplant patients
In 29 renal transplant patients and 29 healthy controls, CETP Taq1B genotype frequencies for B1B1, B1B2, and B2B2 were 44.8%, 34.5%, and 20.7% in patients versus 37.9%, 37.9%, and 24.2% in controls. Transplant patients with the B1B1 genotype had significantly higher total cholesterol, triglycerides, LDL-cholesterol, VLDL-cholesterol, and diastolic blood pressure than other genotypes (P<.05), and patients carrying a B1 allele had significantly higher total cholesterol, LDL-cholesterol, VLDL-cholesterol, and diastolic blood pressure than healthy controls (P<.05). The CETP Taq1B B1 allele and B1B1 genotype are therefore associated with a worse serum lipid profile and higher blood pressure among renal transplant patients.
Original abstract
Background: Dyslipidemia is an important complication in renal transplant patients. Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester between high density lipoproteins and low density lipoproteins. The aim of this study was to investigate CETP Taq1B gene polymorphism and lipid abnormalities in renal transplant patients.
Methods: We studied 29 renal transplant patients and 29 healthy controls. CETP Taq1B polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism techniques. Serum lipid levels were measured enzymatically. Statistical analyses was performed by SPSS for Windows version 7.5.
Results: The frequencies of CETP Taq1B B1B1, B1B2, and B2B2 genotypes in patients were 44.8%, 34.5%, and 20.7%; and in control subjects, 37.9%, 37.9%, and 24.2%, respectively. The patients with B1B1 genotype displayed higher levels of total cholesterol (TC), triglycerides, low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), and diastolic blood pressure (DBP). (P<.05). Also, patients showing a B1 allele had higher levels of TC, LDL-C, VLDL-C, and DBP compared to healthy controls (P<.05).
Conclusion: We observed that CETP Taq1B B1 allele and B1B1 genotype have effects on the serum lipid profile among renal transplant patients.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.