Genetics
CETP is one of only four genes with consistent lipid effects across sex and race in the CARDIA cohort (Arterioscler Thromb Vasc Biol 2006)
Original title: Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants
Genotyping an average of five SNPs across each of 45 genomic regions (54 genes) in the reverse cholesterol transport pathway in 1,131 black women, 812 black men, 1,102 white women, and 954 white men from the CARDIA study, researchers identified 14 SNPs in 6 candidate gene regions with statistically significant, consistent effects on lipid traits across both genders within at least one race, and haplotype analysis identified 9 gene regions with significant effects in one or both races. Of these, four gene regions -- ABCA1, the APOA1/C3/A4/A5 cluster, the APOE/C1/C4/C2 cluster, and CETP -- explained plasma lipoprotein variation most consistently across all strata, while CYP7A1, LPL, PPARA, SOAT1, and SREBF2 showed race-specific effects.
Original abstract
Objective: To identify common variations in genes in the reverse cholesterol transport pathway with nongender-specific influence on plasma lipid and apolipoprotein levels.
Methods And Results: An average of 5 single nucleotide polymorphisms (SNPs) were genotyped within each of 45 genomic regions (54 genes) in blacks (1131 females and 812 males) and whites (1102 females and 954 males) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. SNPs and gene-based 3-SNP haplotypes were evaluated for their ability to predict variation in plasma apolipoproteins (apo) A-I and apoB, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides (TG). We identified 14 SNPs in 6 candidate gene regions that explained statistically significant variation in the same trait in both genders of at least one race and with evidence of consistent genotype mean trend across gender within race. Haplotype analyses identified 9 candidate gene regions that explained statistically significant variation in one or both races.
Conclusions: Four gene regions, ABCA1, APOA1/C3/A4/A5, APOE/C1/C4/C2, and CETP, explained plasma lipoprotein variation most consistently across strata. Other gene regions that influence plasma lipid and apolipoprotein levels within race include CYP7A1, LPL, PPARA, SOAT1, and SREBF2.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.