LDL and apoB
Elevated CETP levels track with oxidized LDL in dyslipidemic patients (Clin Biochem 2007)
Original title: CETP and oxidized LDL levels increase in dyslipidemic subjects
In 200 subjects with various dyslipidemias, CETP and oxidized LDL (Ox-LDL) were measured by ELISA alongside LDL lipid content. CETP levels were significantly increased in subjects with mixed hyperlipidemia and hypercholesterolemia compared with controls, while Ox-LDL was significantly increased only in mixed hyperlipidemia. The triglyceride-to-cholesterol ratio in LDL rose significantly across dyslipidemia types, most in hypertriglyceridemic subjects and least in hypercholesterolemic subjects. Multiple regression showed VLDL total cholesterol and triglycerides were significantly related to CETP (R2=0.066), and triglycerides and total cholesterol were significantly related to Ox-LDL (R2=0.094), supporting a model in which high CETP reshapes LDL lipid composition and thereby raises in vivo Ox-LDL, contributing to atherogenesis in dyslipidemia.
Original abstract
Objectives: To explore the possible associations among cholesteryl ester transfer protein (CETP), contents of lipids in low-density lipoprotein (LDL), and in vivo oxidized LDL (Ox-LDL).
Design And Methods: CETP and Ox-LDL were both detected by ELISA. Their levels and the lipid contents of LDL were investigated in 200 subjects with various dyslipidaemias.
Results: Compared to the control, CETP levels were significantly increased in subjects with mixed hyperlipidaemia and hypercholesterolaemic. Ox-LDL levels were only significantly increased in mixed hyperlipidaemia subjects. Triacyglycerols to cholesterol ratio in LDL was significantly increased in various dyslipidaemias subjects, of which, hypertriglyceridaemic subjects exhibited the most significant change, while hypercholesterolaemic subjects the least. Multiple linear regression analysis showed that total cholesterol and triacyglycerols levels in very low-density lipoprotein were significantly related with CETP (R(2)=0.066), and triacyglycerols and total cholesterol levels were significantly related with Ox-LDL (R(2)=0.094), respectively.
Conclusions: High CETP promotes the transport of lipids among lipoproteins, which changed the lipid composition of LDL, resulting in the increase of in vivo Ox-LDL level, and subsequently contributing to the atherogenic process in dyslipidaemias subjects.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.