Genetics
CETP TaqIB predicts HDL cholesterol in one Chinese ethnic minority but not in neighboring Han Chinese (J Investig Med 2008)
Original title: Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations
This study compared the CETP TaqIB gene polymorphism and its association with serum lipid levels between the Guangxi Hei Yi Zhuang (n=758) and Han Chinese (n=778) populations, genotyping by PCR-RFLP confirmed by direct sequencing. HDL-cholesterol and apolipoprotein AI levels were significantly higher in B2B2 than B1B1 genotype carriers in Hei Yi Zhuang (P less than 0.01 for each), but not in Han Chinese. In Hei Yi Zhuang, higher HDL-cholesterol in B2B2 carriers was seen only in females, nondrinkers, nonsmokers, those with BMI 24 kg/m2 or lower, or normotensives, while in Han Chinese, higher HDL-cholesterol was seen only in females with B2B2 or in those with BMI 24 kg/m2 or lower or normotensives with B1B2. HDL-cholesterol was higher in drinkers than nondrinkers among B1B1 and B1B2 carriers in both groups. The authors conclude the CETP-HDL association differs between these two ethnic groups, suggesting either non-causal involvement or an ethnic-specific effect.
Original abstract
Background: Cholesteryl ester transfer protein (CETP) plays an important role in lipoprotein metabolism. The present study was undertaken to compare the difference in the CETP TaqIB gene polymorphism and its association with serum lipid levels between the Guangxi Hei Yi Zhuang and Han populations.
Methods: A total of 758 subjects of Hei Yi Zhuang and 778 participants of Han Chinese were surveyed. Genotyping of the CETP TaqIB was performed using polymerase chain reaction and restriction fragment length polymorphism and then confirmed using direct sequencing.
Results: The genotypic and allelic frequencies were significant differences between smokers and nonsmokers, or between hypertensives and normotensives in Hei Yi Zhuang, and between drinkers and nondrinkers in Han. The levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein AI in Hei Yi Zhuang but not in Han were higher in B2B2 genotype than in B1B1 genotype (P < 0.01 for each). Higher HDL-C levels in Hei Yi Zhuang were found only in females, nondrinkers, nonsmokers, subjects with a body mass index of 24 kg/m or lesser, or normotensives in B2B2 genotype. Higher HDL-C levels in Han were found only in females in B2B2 genotype and in subjects with a body mass index of 24 kg/m or lesser or normotensives in B1B2 genotype. The levels of HDL-C in B1B1 and B1B2 individuals in both ethnic groups were higher in drinkers than in nondrinkers.
Conclusions: There were significant differences in the interactions between the CETP TaqIB genotypes and several environmental factors in the Hei Yi Zhuang and Han populations. The polymorphism predicted differences in HDL-C and ApoAI in the Hei Yi Zhuang but not in the Han Chinese, even after adjustment for confounding variables. This means that the gene may not be truly involved in regulation of high-density lipoprotein metabolism or that there is an ethnic-specific effect.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.