Genetics
CETP B1B1 genotype nearly triples coronary heart disease risk in a South Indian population (Clin Chim Acta 2009)
Original title: Cholesteryl ester transfer protein TaqIB, -629C>A and I405V polymorphisms and risk of coronary heart disease in an Indian population
Researchers genotyped CETP TaqIB, -629C>A, and I405V polymorphisms in 504 confirmed coronary heart disease (CHD) cases and 338 matched controls from the Tamilian population of south India. Multivariate logistic regression found CETP B1B1 (TaqIB) and CA (-629C>A) genotypes significantly associated with increased CHD risk (odds ratio 2.7, 95% CI, 1.5-3.3, and odds ratio 1.5, 95% CI, 1.1-2.4, respectively), with combined wild-type and combined heterozygous-mutant genotypes also showing associations. Subgroup analysis found men carrying B1B1 or CA genotypes at significantly higher CHD risk (B1B1: odds ratio 2.7, 95% CI, 1.7-4.3; CA: odds ratio 1.8, 95% CI, 1.3-2.6), and the associations were significant specifically among non-hypertensive CHD patients; no link was found between the I405V polymorphism and CHD. The authors conclude CETP B1B1 and CA genotypes confer greater CHD risk particularly in non-hypertensive and male patients.
Original abstract
Background: Polymorphisms in cholesteryl ester protein gene have been linked to risk of coronary heart disease (CHD) in many world populations through their effect on reverse cholesterol transport.
Methods: Five hundred four (504) unrelated electrocardiograph confirmed cases of CHD and 338 population based controls, matched by age and gender, belonging to the Tamilian population of south India were genotyped for polymorphisms in CETP gene using PCR RFLP methods.
Results: The multivariate logistic regression analyses demonstrated that CETP B1B1 and CA genotypes of TaqIB and -629C>A were significantly associated with increased risk for CHD (odds ratio (OR) 2.7; 95% confidence intervals (CI) (1.5-3.3); OR 1.5 (1.1-2.4)) respectively. Combined wild genotypes of CETP gene showed an association with CHD (OR-1.7 (1.0-2.9) as well as the combined heterozygous mutants (OR 1.5 (1.0-2.3); p-0.03). Subgroup analysis based on gender revealed that men harboring CETP B1B1 and CA genotypes have a significant risk for CHD B1B1- 2.7 (1.7-4.3), CA-1.8 (1.3-2.6). There was no link between CETP I450V polymorphism and CHD. Analysis based on hypertensive status showed a significant association between these polymorphisms and non hypertensive CHD patients.
Conclusions: The risk in non hypertensive and male CHD patients is higher in the presence of CETP B1B1 and CA genotypes.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.