Genetics
CETP TaqIB B1B1 men are most responsive to a high-carbohydrate low-fat diet's HDL-raising effect in young Chinese adults (J Nutr Biochem 2010)
Original title: TaqIB polymorphism in the CETP gene modulates the impact of HC/LF diet on the HDL profile in healthy Chinese young adults
Fifty-six healthy young Chinese Han adults (mean age 22.89 years) followed a 7-day washout diet (31% fat, 54% carbohydrate) then a 6-day high-carbohydrate low-fat (HC/LF) diet (15% fat, 70% carbohydrate) without energy restriction, with CETP TaqIB and LDLR PvuII genotyped alongside lipid profiles. Carriers of the CETP TaqIB B2 allele had significantly higher HDL-C and apoA-I than B1B1 carriers after the diet intervention across the whole population, but notably, men with the B1B1 genotype specifically showed significantly increased HDL-C and apoA-I after the HC/LF diet, indicating this genotype's HDL-C level is more sensitive to carbohydrate-fat diet composition even though B2 carriers have higher HDL-C overall.
Original abstract
The aim of this study was to investigate the interactions of genetic variants in the genes of cholesterol ester transfer protein (CETP) and low-density lipoprotein receptor (LDLR) with high carbohydrate and low fat (HC/LF) diet on lipid profiles in a young and healthy Chinese Han population. Fifty-six healthy subjects (22.89±1.80 years) were given washout diets of 31% fat and 54% carbohydrate for 7 days, followed by HC/LF diets of 15% fat and 70% carbohydrate for 6 days, with no total energy restriction. Serum lipid profiles at baseline, after washout and following HC/LF diets, as well as CETP and LDLR polymorphisms were analyzed. Carriers of B2 allele of CETP TaqIB polymorphism had significantly higher levels of high density lipoprotein cholesterol (HDL-C) and apo A-I in the whole study population after the diet intervention. Notably, males with CETP TaqIB B1B1 experienced significantly increased HDL-C and apo A-I after HC/LF diet. Regarding the LDLR Pvu II polymorphism, both P1P1 subjects and P2 carriers experienced decreased total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels after HC/LF diet with no statistically significant differences between the genotypes. Our results demonstrate that the elevated HDL-C levels after HC/LF diet in healthy Chinese Han youth are associated with CETP TaqI B2 allele while males with B1B1 genotype are more susceptible to the influence of HC/LF diet on their HDL-C levels. The decreased TC and LDL-C levels after HC/LF diet are not associated with LDLR Pvu II polymorphism.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.