Genetics
CETP Taq1B B1B1 genotype independently raises type 2 diabetes risk, and a hepatic lipase variant amplifies it further (PLoS One 2011)
Original title: Interaction between cholesteryl ester transfer protein and hepatic lipase encoding genes and the risk of type 2 diabetes: results from the Telde study
This case-control study from the population-based Telde cohort assessed the effects of the CETP Taq1B polymorphism (rs708272) and the LIPC G-250A polymorphism (rs2070895) on type 2 diabetes (T2D) risk, classifying 115 diabetic and 116 pre-diabetic subjects by oral glucose tolerance test, with 226 normal glucose tolerance subjects as matched controls. The B1B1 Taq1B CETP genotype frequency increased with worsening glucose metabolism (42.5%, 46.1%, and 54.3% in control, pre-diabetic, and diabetic groups; p=0.042), and was independently associated with increased diabetes risk (OR 1.828, 95% CI 1.12-2.99, p=0.016) after adjusting for confounders, while the LIPC polymorphism was not independently associated. Among B1B1 genotype carriers, absence of the LIPC minor A allele further increased diabetes risk. The authors conclude the CETP B1B1 genotype contributes to diabetes independently of age, sex, BMI, and waist circumference, with the LIPC GG genotype amplifying this risk in B1B1 carriers.
Original abstract
Background And Aim: Diabetic dyslipidaemia is common in type 2 diabetes (T2D) and insulin resistance and often precedes the onset of T2D. The Taq1B polymorphism in CETP (B1 and B2 alleles) (rs708272) and the G-250A polymorphism in LIPC (rs2070895) are associated with changes in enzyme activity and lipid concentrations. Our aim was to assess the effects of both polymorphisms on the risk of T2D.
Methods And Results: In a case-control study from the population-based Telde cohort, both polymorphisms were analysed by PCR-based methods. Subjects were classified, according to an oral glucose tolerance test, into diabetic (N = 115) and pre-diabetic (N = 116); 226 subjects with normal glucose tolerance, matched for age and gender, were included as controls. Chi-square (comparison between groups) and logistic regression (identification of independent effects) were used for analysis. The B1B1 Taq1B CETP genotype frequency increased with worsening glucose metabolism (42.5%, 46.1% and 54.3% in control, IGR and diabetic group; p = 0.042). This polymorphism was independently associated with an increased risk of diabetes (OR: 1.828; IC 95%: 1.12-2.99; p = 0.016), even after adjusting by confounding variables, whereas the LIPC polymorphism was not. Regarding the interaction between both polymorphisms, in the B1B1 genotype carriers, the absence of the minor (A) allele of the LIPC polymorphism increased the risk of having diabetes.
Conclusion: The presence of the B1B1 Taq1B CETP genotype contributes to the presence of diabetes, independently of age, sex, BMI and waist. However, among carriers of B1B1, the presence of GG genotype of the -250 LIPC polymorphism increases this risk further.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.