CETP B1 allele raises coronary artery disease and diabetes risk independent of HDL-C in western Iran (Genet Test Mol Biomarkers 2011)

Original title: Association between cholesteryl ester transfer protein TaqIB variants and risk of coronary artery disease and diabetes mellitus in the population of western Iran

Genet Test Mol Biomarkers · 20 June 2011 · 5

Rahimi Z, Nourozi-Rad R, Vaisi-Raygani A, Saidi MR, Rahimi Z, Ahmadi R, Yarani R, Hamzehee K, Parsian A

Researchers examined the CETP TaqIB polymorphism in 207 patients with coronary artery disease (CAD), 101 with type 2 diabetes mellitus (T2DM), and 92 controls from western Iran. The CETP B1 allele was significantly associated with increased risk of both CAD (odds ratio 1.65; 95% CI, 1.2-2.3; p=0.005) and T2DM (odds ratio 1.7; 95% CI, 1.13-2.54; p=0.005), and this association with CAD persisted after adjusting for age, sex, hypertension, diabetes, and hyperlipidemia (odds ratio 1.9; 95% CI, 1-3.6; p=0.049). No association was found between CETP alleles and triglycerides, total cholesterol, LDL-C, or HDL-C levels in any group. The authors conclude the CETP B1 allele raises CAD and T2DM risk independent of plasma HDL-C in this population.

Original abstract

Aims: To shed light on the previously inconsistent results about the association of cholesteryl ester transfer protein TaqIB (CETP TaqIB) variants, high-density lipoprotein cholesterol (HDL-C) levels, and the risk of coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).

Methods: To determine the frequency of CETP TaqIB variants and to examine the possible association between CETP TaqIB polymorphism with CAD and T2DM, we studied 207 unrelated patients with CAD, 101 patients with T2DM, and 92 controls. The CETP TaqIB variants were detected by polymerase chain reaction-restriction fragment length polymorphism.

Results: Logistic regression analysis indicated that the B1 allele of CETP was significantly associated with increased risk of CAD (odds ratio, OR 1.65 [95% confidence interval, CI 1.2-2.3, p=0.005]) and T2DM (OR 1.7 [95% CI 1.13-2.54, p=0.005]). Adjusted logistic regression analysis for the effects of age, sex, hypertension, diabetes, and hyperlipidemia was performed; and a significant association was found between the B1 allele and risk of CAD (OR 1.9 [95% CI 1-3.6, p=0.049]) in patients with CAD. There were no associations between the CETP alleles and the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and HDL-C in studied groups.

Conclusions: The results of the present study revealed that the CETP B1 allele is associated with increased risk of CAD and T2DM independent of plasma HDL-C level in our population.

Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.