Genetics
Meta-analysis confirms CETP TaqIB polymorphism is linked to coronary artery disease in Chinese patients (J Zhejiang Univ Sci B 2012)
Original title: Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population
This meta-analysis assessed whether the CETP TaqIB polymorphism is associated with coronary artery disease (CAD) in the Chinese population, searching PubMed, Embase, SCI, and three Chinese databases. From 448 studies identified, 10 case-control studies including 1694 cases and 1456 controls met selection criteria, with combined B1 and B2 allele frequencies of 0.587 and 0.413 respectively. The pooled odds ratio was 1.10 (95% CI 0.89-1.34) comparing B1B1 or B1B2 carriers to B2B2 carriers, and 1.27 (95% CI 1.09-1.49) comparing B1B1 carriers to B2B2 or B1B2 carriers. The authors conclude the CETP TaqIB polymorphism is associated with CAD in the Chinese population.
Original abstract
Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper.
Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
Results: The literature search yielded 448 studies, in which 10 case-control studies including 1694 cases and 1456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89-1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09-1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers.
Conclusions: In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the Chinese population.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.