CETP genotype frequencies do not differ between centenarians, nonagenarians, and average-lifespan controls (Angiology 2013)

Original title: The frequency of 4 common gene polymorphisms in nonagenarians, centenarians, and average life span individuals

Angiology · 6 February 2013 · 4

Kolovou G, Kolovou V, Vasiliadis I, Giannakopoulou V, Mihas C, Bilianou H, Kollia A, Papadopoulou E, Marvaki A, Goumas G, Kalogeropoulos P, Limperi S et al.

Researchers compared the frequency of CETP variants rs708272 (TaqB1) and rs5882 (I405V), alongside ACE and NFkB variants, across 190 nonagenarians, 12 centenarians, and 105 middle-aged controls. While ACE I/D genotype frequencies differed significantly between the groups (fewer I carriers in nonagenarians than centenarians, P = .016, and more I carriers in centenarians than controls, P = .045), no differences in the frequency of common CETP or NFkB genotypes were observed between the exceptional-longevity groups and middle-aged controls. The study provides a clean direct null result for these specific CETP variants as markers of exceptional human longevity.

Original abstract

Single nucleotide polymorphisms of angiotensin-converting enzyme (ACE) such as rs1799752, nuclear factor kappa B (NFkB) such as rs28362491 and cholesteryl ester transport protein (CETP) such as rs708272 (TaqB1) and rs5882 (I405V) were evaluated in nonagenarians, centenarians, and average life span individuals (controls). The study population (n = 307; 190 nonagenarians, 12 centenarians and 105 middle-aged controls) was genotyped for ACE, NFkB, and CETP genetic variants. The age of nonagenarian and centenarian group ranged between 90 and 111 years; centenarians and controls age ranged from 99 to 111, and from 18 to 80 years, respectively. The I carriers of ACE I/D gene were fewer in nonagenarians compared to centenarians (37.6% vs 62.5%, P = .016). The I carriers of ACE gene were more frequent in centenarians compared to controls (62% vs 41%, P = .045). No differences in frequency of common NFkB and CETP genotypes between patients with exceptional longevity and middle-aged patients were observed.

Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.