Longevity 29 items
The exceptional-ageing literature and what it does and does not say about CETP.
Studies
- Landmark study links large HDL and LDL particle size and the CETP 405 valine allele to exceptional human longevity (JAMA 2003)
- The CETP 405-valine allele is identified as the first genotype linked to inherited exceptional human longevity (Mech Ageing Dev 2005)
- Landmark Omagari study first shows CETP-deficiency-driven high HDL cholesterol is not a longevity syndrome (Arterioscler Thromb Vasc Biol 1997)
- CETP inhibition as a longevity pathway: apoB lowering, not HDL raising, is the mechanism, with signals in diabetes, dementia and kidney disease (Curr Opin Lipidol 2024)
- Drug-target Mendelian randomization links genetically lower CETP to longer human lifespan (Aging 2023)
- CETP I405V reverses direction: protective for longevity in Ashkenazi Jews but a risk allele in Chinese (PLoS One 2013)
- A longevity-associated CETP genotype preserves cognitive function in two independent cohorts (Neurology 2006)
- Combined CETP and hepatic lipase deficiency drives atherosclerotic disease in some patients with marked high HDL (Arterioscler Thromb Vasc Biol 1995)
- Mendelian randomisation across nine drug targets and half a million lifespans finds genetically proxied CETP inhibition extends life expectancy (Lipids Health Dis 2023)
- Lower serum CETP levels found in the oldest members of Greek long-lived families (Open Cardiovasc Med J 2018)
- CETP TaqIB and I405V variants strongly linked to centenarian status in Hainan, China (Asian Pac J Trop Med 2016)
- CETP and APOE variants interact to raise hypertriglyceridemia risk in oldest-old Chinese women (Exp Gerontol 2014)
- CETP deficiency linked to cardiovascular disease and stroke within a high-HDL syndrome, especially in women (Mol Genet Metab Rep 2014)
- CETP variant rs9923854 enriched in the oldest-old across Danish and German cohorts (Age (Dordr) 2012)
- CETP I405V shows no link to age or cardiovascular disease despite raising HDL cholesterol (BMC Geriatr 2016)
- Policosanol-loaded reconstituted HDL inhibits CETP activity by up to 47 percent and promotes tissue regeneration (Rejuvenation Res 2015)
- CETP gene promoter variants show no association with longevity in two Han Chinese samples (Mol Biol Rep 2013)
- CETP TaqIB genotype tracks with HDL-C differently in long-lived versus younger Chinese Bama Zhuang adults (Lipids Health Dis 2012)
- CETP TaqIB genotype distinguishes a longevity syndrome of simultaneously high HDL and LDL cholesterol (Open Cardiovasc Med J 2010)
- A CETP gene variant favors healthy survival past age 90 in long-lived Japanese-American men (J Gerontol A Biol Sci Med Sci 2008)
- CETP I405V fails to replicate as a longevity gene in a large American Caucasian cohort (Biogerontology 2007)
- The favorable CETP-VV genotype is found to buffer the deleterious effect of the lipoprotein(a) gene in exceptionally long-lived Ashkenazi Jews (PLoS Comput Biol 2007)
- CETP I405V VV genotype is twice as common in people over 89 as in young adults, and linked to fewer vascular events (Arch Gerontol Geriatr 2006)
- CETP I405V and healthy aging link does not replicate in Italian centenarians (Mech Ageing Dev 2005)
- Review examines conflicting evidence on CETP genetic variation and longevity in centenarians (J Atheroscler Thromb 2004)
- CETP deficiency raises HDL cholesterol in Japanese centenarians but does not affect longevity (J Mol Med (Berl) 2003)
- CETP mass varies widely in healthy Japanese people with very high HDL cholesterol (Intern Med 2002)
- Whole-body model finds high-activity CETP genotypes raise LDL-C more with ageing than low-activity genotypes (Biosystems 2016)
- CETP genotype frequencies do not differ between centenarians, nonagenarians, and average-lifespan controls (Angiology 2013)