Genetics
CETP I405V polymorphism is an independent risk factor for endometriosis in a case-control study of women (Gynecol Endocrinol 2013)
Original title: I405V polymorphism of CETP gene and lipid profile in women with endometriosis
Comparing ninety-seven women with laparoscopy-diagnosed endometriosis to 107 laparoscopy-confirmed controls, researchers genotyped the CETP I405V polymorphism and assessed its relationship to lipid profile and endometriosis risk. After adjusting for body mass index, HDL-C, and LDL-C, the risk of endometriosis was significantly lower in women homozygous for the normal (wild-type) genotype compared with rare-allele carriers (P less than 0.001, odds ratio 0.21, 95% CI 0.09 to 0.45). The authors conclude that the CETP I405V polymorphism functions as an independent risk factor for endometriosis in women, adding CETP genetics to the known role of lipid and inflammatory abnormalities in the disease's pathophysiology.
Original abstract
Genetic factors have an important role in the pathophysiology of endometriosis. In addition, abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP) gene and lipid profile with the risk of endometriosis in women. Ninety-seven women with laparoscopy-diagnosed endometriosis were recruited for this study, and 107 patients with no evidence of endometriosis confirmed by laparoscopy served as controls. Samples were analyzed for polymorphism of the CETP gene using polymerase chain reaction-restriction fragment length polymorphism-based methods. After adjustment for body mass index, high-density lipoprotein-C and low-density lipoprotein-C, the risk of endometriosis in patients with normal genotype homozygous was more of the rare allele (p < 0.001, odds ratio = 0.21, 95% confidence interval = 0.09-0.45). Our results suggest that I405V polymorphism of CETP gene plays an important role as independent factor in the risk of endometriosis in women.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.