Genetics
CETP G allele carriers show distinct waist circumference and metabolic profiles, independent of glucose and lipid changes (Diabetes Res Clin Pract 2014)
Original title: Study to assess whether waist circumference and changes in serum glucose and lipid profile are independent variables for the CETP gene
This study assessed correlations among serum glucose, lipids, waist circumference (WC), and the Taq1B, I405V, and D442G polymorphisms of the CETP gene, to evaluate whether obesity-related disease results from genetic or obesity-driven factors, using logistic regression to screen independent variables among obesity-related anthropometric indexes and serum biochemical indicators for the CETP gene. The waist circumference density index (WCDI) could be attributed to changes in serum biochemical indicators, but among WCDI, BMI, and serum biochemical indicators, only WCDI was found to be an independent variable for the CETP G allele. Anthropometric indexes and serum biochemical indicators differed significantly between subjects with and without the G allele (p less than 0.05). The authors conclude that abdominal obesity and glucose/lipid profile changes are affected by a group of genes including CETP, with the CETP-waist circumference correlation independent of serum glucose and lipid profile.
Original abstract
Aims: To observe the relationship among genes, obesity and the changes in serum glucose and lipid profile to assess whether obesity-related disease results from genes and/or obesity.
Methods: Correlations among serum glucose, lipids, waist circumference (WC), and Taq1B, I405V, and D442G polymorphisms of the cholesteryl ester transfer protein (CETP) gene were assessed. Logistic regression analysis was used to screen independent variables among obesity-related anthropometric indexes and serum biochemical indicators for genes.
Results: The waist circumference density index (WCDI) may be attributed to changes in serum biochemical indicators and among WCDI, BMI and serum biochemical indicators, however, only WCDI was an independent variable for the G allele. Differences were observed in anthropometric indexes and serum biochemical indicators between subjects with the G allele and those without (p<0.05).
Conclusion: Abdominal obesity and changes in serum glucose and lipid profile are affected by a group of genes, including CETP. Correlation of the CETP gene with waist circumference may be independent compared with serum glucose and lipid profile.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.