Genetics
CETP variant rs5882 G allele is linked to lower HDL cholesterol in obese and non-obese individuals alike (Gene 2015)
Original title: The lipoprotein lipase S447X and cholesteryl ester transfer protein rs5882 polymorphisms and their relationship with lipid profile in human serum of obese individuals
This study explored the association of the LPL rs328 and CETP rs5882 polymorphisms with lipid profile in 271 individuals (151 obese, 120 non-obese), using univariate and multivariate analyses to evaluate associations with obesity and lipid components. Obese subjects had significantly higher triglycerides, blood pressure, waist circumference, and fasting blood glucose, and lower HDL-cholesterol, than non-obese subjects. Neither LPL nor CETP polymorphisms were associated with obesity itself. However, the LPL rs328 GG-GC genotype was significantly related to higher triglycerides compared to the CC wild-type, and to higher HDL-cholesterol in the obese group compared to controls. Obese subjects carrying the CETP G allele had significantly lower HDL-cholesterol (p less than 0.05) than those with the C allele. The authors conclude LPL and CETP polymorphisms are significantly associated with serum triglycerides and HDL-cholesterol.
Original abstract
Background: Obesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity.
Subjects/Methods: Genotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components.
Results: Obese subjects had a significantly (P<0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P<0.05) compared to those with C allele.
Conclusion: We demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.