Genetics
Total fat intake modifies the CETP Taq1B link to HDL cholesterol only in type 2 diabetes patients without dyslipidemia (Clin Nutr 2018)
Original title: Differences in the interaction between CETP Taq1B polymorphism and dietary fat intake on lipid profile of normolipedemic and dyslipidemic patients with type 2 diabetes mellitus
This comparative study examined the frequency of CETP Taq1B polymorphism and its interaction with dietary fat intake on HDL-cholesterol (HDL-c) concentration in Iranian type 2 diabetes mellitus (T2DM) patients with (n=55) and without (n=129) dyslipidemia, using a validated food frequency questionnaire and PCR-RFLP genotyping. The B1B1 genotype was more frequent in patients with dyslipidemia (p=0.01), but there was no significant relationship overall between CETP Taq1B polymorphism and lipid profile concentrations. In patients without dyslipidemia, the interaction between the polymorphism and total fat intake was significant for HDL-c concentration (p=0.02) and the triglyceride to HDL ratio (p=0.009), more evident in the B1B1 genotype, and HDL-c was significantly higher in B2B2 genotype carriers with low total fat intake. The authors conclude higher total fat intake may affect the CETP Taq1B-HDL-c relationship in normolipidemic T2DM patients.
Original abstract
Background & Aim: Dyslipidemia is one of the major complications in patients with type 2 diabetes mellitus (T2DM). Dietary fat intake and genetic factors including CETP Taq1B polymorphism could also affect lipid profile concentrations, in particular HDL-c. We decided to study the frequency of this polymorphism and its interaction with dietary fat intake on HDL-c concentration among Iranian T2DM patients with and without dyslipidemia.
Methods: In this comparative study, serum samples were collected from 55 patients with dyslipidemia and 129 patients without dyslipidemia. Validated semi-quantitative FFQ was used for food consumption data. CETP Taq1B polymorphism was studied by polymerase chain reaction-restriction length polymorphism (PCR-RFLP). We used χ2 and two-way ANOVA tests for statistical analysis.
Results: The frequency of B1B1 genotype was higher in patients with dyslipidemia (p = 0.01). There was no significant relationship between CETP Taq1B polymorphism and lipid profile concentrations. In patients without dyslipidemia, the interaction between the polymorphism and total fat intake on HDL-c concentration as well as TG/HDL ratio was significant (p = 0.02 and p = 0.009 respectively). This was more evident in B1B1 genotype. Moreover, HDL-c concentration was significantly higher in B2B2 genotype with low total fat intake.
Conclusion: Higher total fat intake may affect the relationship between CETP Taq1B polymorphism and HDL-c concentration in patients with normolipidemic T2DM.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.