Genetics
A protective CETP haplotype, but not individual TaqIB or D442G variants, lowers essential hypertension risk in Chinese Mongolians (Turk J Med Sci 2017)
Original title: Association of the CETP gene TaqIB and D442G polymorphisms with essential hypertension in the Chinese Mongolian population
This case-control study explored the association of CETP gene TaqIB and D442G polymorphisms with essential hypertension (EH) in 883 hypertensive patients and 1044 normal controls randomly selected from the Mongolian population of China, using PCR, direct sequencing, and haplotype analysis. The B2-G haplotype frequency was significantly lower in the EH group than controls (0.7% vs 1.9%, P=0.001, OR=0.359 [0.188-0.689]). Subjects with the B2B2 genotype had significantly lower total cholesterol. In male subjects, the B2B2 genotype was associated with significantly higher HDL-cholesterol and lower total cholesterol, and B2 allele carriers had significantly lower triglycerides than B1B1 homozygotes. The authors conclude that while TaqIB and D442G did not independently affect EH risk, the B2-G haplotype reduced EH susceptibility, and the B2 allele altered blood lipid levels favorably.
Original abstract
Background/Aim: This study aimed to explore the associations of the cholesteryl ester transfer protein (CETP) gene TaqIB and D442G polymorphisms with essential hypertension (EH).
Materials And Methods: In this case-control study, 883 hypertensive patients and 1044 normal controls were randomly selected from the Mongolian population of China. Polymerase chain reaction (PCR) and direct sequencing of PCR products were used to identify the genotypes. Haplotype analysis was performed by estimating the haplotype frequencies using the online SHEsis package.
Results: The distribution frequency of the B2-G haplotype was significantly lower in the EH group than in the control group (0.7% vs. 1.9%, P = 0.001, OR = 0.359 [0.188-0.689]). Subjects with the B2B2 genotype showed significantly lower levels of total cholesterol (TC) (P < 0.05). When subgrouped by sex, male subjects with the B2B2 genotype showed significantly increased high-density lipoprotein cholesterol and decreased TC levels (P < 0.05), and those with the B2 allele showed significantly lower triglyceride levels as compared to the subjects with the B1B1 homozygote (P < 0.05).
Conclusion: TaqIB and D442G polymorphisms of the CETP gene did not independently affect the risk of developing EH in the Chinese Mongolian population, while the B2-G haplotype obviously decreased the susceptibility to EH. The B2 allele could alter the blood lipid level and reduce the risk of developing cardiovascular diseases.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.