Five of six CETP polymorphisms are linked to metabolic syndrome in Uyghur adults, with two protective haplotypes identified (Int J Environ Res Public Health 2017)

Original title: Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China

Int J Environ Res Public Health · 18 June 2017 · 6

Hou H, Ma R, Guo H, He J, Hu Y, Mu L, Yan Y, Ma J, Li S, Zhang J, Ding Y, Zhang M et al.

This study explored the association between six CETP gene polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) and metabolic syndrome (MS) and its components in 571 Uyghur adults (280 with MS, 291 controls) randomly selected from 5692 Uyghur adults in Xinjiang, China. Five of the six polymorphisms, rs1800775, rs3764261, rs12149545, rs711752, and rs708272, showed significant genotype and allele frequency differences between groups and were significantly related to MS risk (all p less than 0.05). rs1800775 was associated with high fasting glucose and low HDL-cholesterol; rs3764261 and rs12149545 were associated with all MS components except high blood pressure; and rs711752 and rs708272 were associated with low HDL-cholesterol. Two haplotypes, A-G-G-G-C (OR=0.622) and A-T-A-A-T (OR=0.519), were more frequent in controls, suggesting they are protective against MS.

Original abstract

Objective: To explore the association between CETP gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the CETP gene polymorphisms and each component of MS.

Methods: A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected CETP polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method.

Results: (1) Significant differences were found involving the frequency distribution of genotypes and alleles of rs1800775, rs3764261, rs12149545, rs711752, and rs708272 between the control and MS groups (all p < 0.05). (2) rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms were significantly related to the risk of MS (all p < 0.05). (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all p < 0.05). (4) Complete linkage disequilibrium (LD) was identified for two pairs of single nucleotide polymorphisms (SNPs) (rs3764261 and rs12149545 (D' = 1.000, r² = 0.931), rs711752 and rs708272 (D' = 1.000, r² = 0.996)). (5) The A-G-G-G-C (p = 0.013, odds ratio [OR] = 0.622, 95% confidence interval [95% CI] = 0.427-0.906) and A-T-A-A-T (p < 0.001, OR = 0.519, 95% CI = 0.386-0.697) haplotypes were more frequent in the control group than in the case group. Conclusions: The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of CETP were associated with MS and its components among the Uyghur ethnic group. Complete LD was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). The A-G-G-G-C and A-T-A-A-T haplotypes might be protective factors for MS.

Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.