Genetics
Iranian case-control study finds no direct link between CETP polymorphism rs708272 and coronary artery disease, but flags a CETP-activity/HDL-C interaction (BMC Cardiovasc Disord 2022)
Original title: Association study between polymorphisms in MIA3, SELE, SMAD3 and CETP genes and coronary artery disease in an Iranian population
A case-control study genotyped 101 coronary artery disease (CAD) patients with at least 50% luminal stenosis and 111 healthy controls in an Iranian population, testing polymorphisms in MIA3, SELE, SMAD3 and CETP genes by ARMS-PCR and RFLP-PCR. The CETP variant rs708272, along with rs17228212 (SMAD3) and rs17465637 (MIA3), showed no significant direct association with CAD risk. Significant associations with CAD emerged for rs5355 and rs3917406 (SELE) in the whole cohort and rs5882 (SELE) in male cases specifically. The authors nonetheless report a significant interaction between CETP SNPs and CETP activity affecting HDL-C levels, distinct from the null direct CAD association, and highlight SELE gene polymorphisms as newly associated with CAD risk in this population.
Original abstract
Background: Coronary artery disease (CAD) is the most common heart disease. Several studies have shown association between some polymorphism in different genes with CAD. Finding this association can be used in order to early diagnosis and prevention of CAD.
Method: 101 CAD patients with ≥ 50% luminal stenosis of any coronary vessel as case group and 111 healthy individuals as control group were selected. the polymorphisms were evaluated by ARMS-PCR and RFLP-PCR methods.
Result: The results of this study show that there is no significant association between rs17228212, rs17465637, and rs708272 and risk of CAD. But there is significant association between risk of CAD and rs5355 (p-value = 0.022) and rs3917406 (p-value = 0.006) in total cases, and rs5882 (p-value = 0.001) in male cases.
Conclusions: Our findings revealed a significant interaction between CETP SNPs and CETP activity for affecting HDL-C levels. The SELE gene is a known cell adhesion molecule with a significant role in inflammation. Studies about possible linkage between SELE gene polymorphisms and the development of CAD are conflicting. We have found a significant association between polymorphisms of SELE gene and risk of CAD.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 18 August 2026. Methods.