Genetics
CETP Taq1B B1B1 genotype is more common in Egyptian metabolic syndrome patients and tracks with lower HDL cholesterol (Diabetes Metab Syndr 2011)
Original title: Taq1B polymorphism of cholesteryl ester transfer protein (CETP) in Egyptian patients with metabolic syndrome
This study evaluated the possible association of the CETP Taq1B polymorphism with metabolic syndrome components in a cohort of Egyptian patients compared to healthy controls, measuring lipid profile, fasting glucose, insulin, and Taq1B genotype by RFLP-PCR. The patient group showed a significantly higher frequency of the B1B1 genotype and a lower frequency of the B2B2 genotype compared to controls. Across all subjects, serum HDL-cholesterol was significantly higher in those with the B2B2 genotype than those with B1B1. In the patient group, age positively correlated with cholesterol, triglycerides, BMI, and waist circumference. The authors conclude Egyptian patients with metabolic syndrome have a higher prevalence of the CETP B1B1 genotype, which is associated with lower serum HDL-cholesterol.
Original abstract
Aim: We aimed at evaluation of the possible association of cholesteryl ester transfer protein (CETP) Taq1B polymorphism with the components of metabolic syndrome in a cohort of Egyptian patients compared to their healthy counterparts.
Patients And Methods: Blood samples were collected for lipid profile, fasting glucose, insulin and routine biochemical tests. The Taq1B genotypes of CETP were determined using RFLP-PCR technique.
Results: The patients group showed a significantly higher B1B1 genotype and lower B2B2 genotype compared to the controls group. Serum HDL-C level was significantly higher in all subjects with the B2B2 genotype compared to those with B1B1 genotype. In the patients group, age positively correlated with cholesterol level, triglycerides, BMI and waist circumference.
Conclusion: Egyptian patients affected with metabolic syndrome have a higher prevalence of B1B1 genotype that is associated with lower serum HDL-C levels.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.