Genetics
The CETP TaqIB B1B2/B2B2 genotype raises the risk of fatty liver disease in Mexican women with gallstones (Metab Syndr Relat Disord 2023)
Original title: Elevated Serum Low-Density Lipoproteins-Cholesterol Levels and B1B2/B2B2 CETP Genotype Are Positively Associated with Nonalcoholic Fatty Liver Disease in Women with Gallstone Disease
In sixty-two Mexican-mestizo women with gallstone disease, researchers examined whether the CETP TaqIB polymorphism, already linked to abnormal serum lipids, relates to nonalcoholic fatty liver disease severity, measuring serum lipids, CETP levels by ELISA, and steatosis extent by Oil-Red-O-stained biopsy. Subjects with the B1B2/B2B2 genotype had a higher percentage degree of steatosis than those with B1B1 (11.95% versus 2.19%, P equals 0.008). Both the B1B2/B2B2 genotype (odds ratio 3.90, P equals 0.04) and elevated LDL cholesterol (odds ratio 3.54, P equals 0.039) significantly increased the risk of nonalcoholic fatty liver disease, providing evidence that CETP TaqIB genotype and elevated LDL cholesterol jointly raise fatty liver disease risk in women with gallstone disease.
Original abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is generated by the interaction between environmental and genetic factors, and the presence of metabolic alterations. Since Taq1B cholesteryl ester transfer protein (CETP) polymorphism is associated with abnormal serum lipid values, it could be related to NAFLD. The aim of this study was to determine the role of the Taq1B CETP polymorphism with serum lipids, anthropometric variables, and the extent of steatosis in Mexican-mestizo women with gallstone disease (GD). Methods: Sixty-two women were enrolled in this cross-sectional study. Serum lipids were determined by dry chemistry. The Taq1B CETP polymorphism was determined by allelic discrimination. CETP serum levels were measured by enzyme-linked immunosorbent assay, and the extent of steatosis with a biopsy staining with Oil-Red-O. Results: Subjects with the B1B2/B2B2 genotype had higher percentage of degree of steatosis than those with B1B1 (11.95% vs. 2.19%, P = 0.008). The B1B2/B2B2 genotype (odds ratio [OR] 3.90 [confidence interval {CI} 95% 1.891-8.536], P = 0.04) and an elevated low-density lipoproteins (LDL)-cholesterol (OR 3.54 [CI 95% 1.042-2.058, P = 0.039) significantly increase the risk for NAFLD. Conclusions: This study provides evidence that the B1B2/B2B2 genotype of CETP and the elevated LDL-cholesterol serum levels increase the risk of NAFLD in women with GD.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.