Genetics
CETP I405V and healthy aging link does not replicate in Italian centenarians (Mech Ageing Dev 2005)
Original title: Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians
The CETP I405V polymorphism had recently been associated with healthy aging in the Ashkenazi Jewish population. To test this in a different ancestry, researchers analysed allele and genotype distributions of the CETP I405V variant in a sample of Italian centenarians. The results did not confirm the association between the I405V variant and healthy aging previously described in Ashkenazi Jews. The authors suggest other gene-environment interactions, rather than this specific CETP variant, contribute to longevity in the Italian population.
Original abstract
A common polymorphism (I405V) in exon 14 of the cholesteryl ester transfer protein (CETP) gene has been recently associated to healthy aging in Ashkenazi Jewish. In order to study this genetic effect in long-lived individuals with a different ethnicity, we analyzed the allele and genotype distributions of the CETP polymorphism a sample of Italian centenarians. Our result does not confirm the association between the I405V CETP variation and the healthy aging phenotype described in the Ashkenazi Jewish population and suggests that other gene environment interactions contribute to longevity.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.