Genetics
CETP TaqIB and I405V variants strongly linked to centenarian status in Hainan, China (Asian Pac J Trop Med 2016)
Original title: CETP polymorphisms confer genetic contribution to centenarians of Hainan, south of China
Researchers genotyped the CETP TaqIB and I405V polymorphisms in 276 centenarians and 301 matched healthy controls from Hainan island, China. Alleles B1 and V were significantly more frequent in centenarians than controls (P less than 0.001), and genotypes B1B1 (odds ratio 0.148) and VV (odds ratio 0.353) were both significantly different between the groups. Several allele combinations, including B1B1-II, B1B1-IV, B1B2-VV, and B2B2-VV, also differed significantly between centenarians and controls, with odds ratios as low as 0.115 to 0.198. The authors conclude these CETP variants and their combinations may contribute to exceptional longevity in this population.
Original abstract
Objective: In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island.
Methods: We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0).
Results: Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0.001. Further analysis implied that genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095-0.230) and VV (P < 0.001 and OR = 0.353, 95% CI = 0.237-0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P < 0.001, OR = 0.128, 95% CI = 0.049-0.329), B1B1-IV (P < 0.001, OR = 0.115, 95% CI = 0.056-0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310-0.920), and B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086-0.453) have significant differences between centenarians and matched healthy individuals from Hainan.
Conclusion: Our results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.
Summary written by cetpinhibition.org from the published abstract; figures as published. Page updated 19 August 2026. Methods.