Assay 45 items

Studies

• TA-8995 (obicetrapib) raises ABCA1-specific cholesterol efflux capacity by 28% and preBeta-1 HDL by 36%, showing functional as well as HDL-C gains (J Clin Lipidol 2016)J Clin Lipidol · January 2016 7
• A new non-steady-state tracer method shows anacetrapib blocks 97% of postprandial triglyceride flux into HDL (J Lipid Res 2016)J Lipid Res · December 2015 6
• The Friedewald formula underestimates LDL-C by 12 mg/dl after anacetrapib treatment, likely from VLDL-C overestimation (J Lipid Res 2013)J Lipid Res · November 2012 6
• A mathematical model shows torcetrapib and JTT-705 inhibit CETP more potently than classic competitive inhibition would predict (J Lipid Res 2009)J Lipid Res · March 2009 6
• First CETP-specific antibody fragments enable a new quantification assay and link plasma CETP to body fat mass (Clin Chem Lab Med 2004)Clin Chem Lab Med · March 2004 6
• Simvastatin lowers plasma CETP only in Japanese patients with elevated baseline CETP levels (Clin Chem 1998)Clin Chem · July 1998 6
• A single-incubation isotopic assay simultaneously measures LCAT esterification and CETP-mediated cholesteryl ester transfer (Atherosclerosis 1990)Atherosclerosis · January 1990 6
• A turmeric compound, calebin A, binds CETP nearly as tightly as torcetrapib in a computational drug-discovery screen (Res Pharm Sci 2026)Res Pharm Sci · July 2026 5
• Molecular dynamics show mixed cholesteryl-ester and triglyceride cargo twists CETP into strained, asymmetric conformations (Phys Chem Chem Phys 2026)Phys Chem Chem Phys · April 2026 5
• Phospholipid plugs inside two side pores of CETP accelerate triglyceride transfer through a newly described 'gliding' mechanism (Comput Struct Biotechnol J 2026)Comput Struct Biotechnol J · January 2026 5
• Multi-stage virtual screening identifies five novel CETP inhibitor lead compounds, confirmed active by biochemical assay (BMC Chem 2024)BMC Chem · May 2024 5
• Newly synthesised fluorinated diaryl sulfonamides reach 100% CETP inhibition in vitro, guided by molecular modelling (Curr Comput Aided Drug Des 2024)Curr Comput Aided Drug Des · January 2024 5
• Molecular dynamics explains why the R201S and double I443W/V198W mutations cripple lipid transfer through CETP by warping its tunnel geometry (Biophys Chem 2023)Biophys Chem · August 2023 5
• Bound phospholipids bend cholesteryl esters into a transferable shape inside CETP, with the N-terminal lipid doing most of the work (J Chem Inf Model 2023)J Chem Inf Model · May 2023 5
• Trifluoromethylated sulfonamides reach 100% CETP inhibition in vitro, guided by induced fit docking and pharmacophore mapping (Med Chem 2023)Med Chem · January 2023 5
• Bacterial iron-chelating pigments called ferroverdins turn out to be potent CETP inhibitors, with 43 new structural variants identified (Biomolecules 2022)Biomolecules · May 2022 5
• Hydrocarbon-stapled peptides jam the self-binding switch of CETP more than fivefold better, a new route to blocking the protein (J Mol Graph Model 2020)J Mol Graph Model · September 2019 5
• The C-terminal bound phospholipid grips CETP more tightly than the N-terminal one, keeping it bent and ready to carry lipids (J Phys Chem B 2018)J Phys Chem B · April 2018 5
• New benzyl benzamide compound inhibits CETP by 82.2% in vitro, with docking confirming it fits the drug pocket (Arch Pharm 2017)Arch Pharm (Weinheim) · November 2017 5
• CETP can carry triglycerides too, not just cholesteryl esters, and simulations show why the slower TG transfer happens (Sci Rep 2017)Sci Rep · July 2017 5
• A new sandwich ELISA measures plasma CETP concentration with under 10% assay variability (Clin Biochem 1999)Clin Biochem · June 1999 5
• A direct LDL isolation technique offers a simpler alternative for measuring CETP activity (Clin Chim Acta 1997)Clin Chim Acta · October 1997 5
• N-alkylated benzazepine derivatives inhibit CETP with an IC50 of 75.54 ± 8.70 nM in a fluorescence assay (Bioorg Chem 2026)Bioorg Chem · September 2026 4
• Machine learning and molecular dynamics show why obicetrapib binds the CETP hydrophobic tunnel more tightly than the failed torcetrapib (ChemMedChem 2025)ChemMedChem · October 2025 4
• A validated mass spectrometry assay quantifies anacetrapib in fat tissue across three animal species and humans (Bioanalysis 2024)Bioanalysis · January 2024 4
• Proteomic profiling flags CETP as one of three ELISA-confirmed markers elevated in stent restenosis (Front Cardiovasc Med 2022)Front Cardiovasc Med · January 2022 4
• Formulation science: a lipid-based delivery system boosts oral absorption of the CETP inhibitor CP-532,623, and supersaturation, not just solubility, predicts how well (Mol Pharm 2017)Mol Pharm · November 2017 4
• Review collates the bioanalytical methods developed to quantify anacetrapib, dalcetrapib, and torcetrapib in biological samples (Biomed Chromatogr 2013)Biomed Chromatogr · May 2013 4
• Adding a bile correction factor sharpens allometric prediction of human pharmacokinetic parameters for orally dosed torcetrapib (Eur J Drug Metab Pharmacokinet 2009)Eur J Drug Metab Pharmacokinet · January 2009 4
• A new LC-MS/MS assay quantifies torcetrapib in hamster and dog plasma down to 1 nanogram per mL (Biomed Chromatogr 2008)Biomed Chromatogr · March 2008 4
• A chiral HPLC method separates the two torcetrapib enantiomers in hamster plasma down to 0.1 microgram per mL (J Chromatogr B 2007)J Chromatogr B Analyt Technol Biomed Life Sci · August 2007 4
• New fluorescence quencher triples the signal window of a CETP activity assay for large-scale drug screening (Anal Biochem 2007)Anal Biochem · June 2007 4
• New monoclonal-antibody immunoassays quantify CETP mass down to nanogram levels in plasma and cell culture (J Lipid Res 1995)J Lipid Res · April 1995 4
• The first competitive ELISA for CETP detects 1 nanogram per well with a coefficient of variation under 6% (Clin Chim Acta 1994)Clin Chim Acta · December 1994 4
• A fast two-site immunoassay measures CETP mass in 6 hours with under 9% assay variability (Clin Chem 1994)Clin Chem · April 1994 4
• A polyclonal-antibody immunoradiometric assay detects CETP down to 0.1 nanograms with under 9% variability (J Lipid Res 1993)J Lipid Res · April 1993 4
• A chiral HPLC method resolves the methyl ester of evacetrapib from its stereoisomers and five impurities (J Chromatogr A 2015)J Chromatogr A · September 2015 3
• A brush-type Whelk-O 1 chiral column resolves evacetrapib from its enantiomer, two diastereomers, and six impurities (J Chromatogr A 2014)J Chromatogr A · March 2014 3
• Isotope-labeled anacetrapib and its metabolites are synthesized to support bioavailability and drug-metabolism studies (J Labelled Comp Radiopharm 2013)J Labelled Comp Radiopharm · July 2013 3
• A review catalogs the chiral and achiral bioanalytical methods developed to measure torcetrapib across six species (Bioanalysis 2009)Bioanalysis · June 2009 3
• A hidden CETP gene variant caused false positives in fluorescence-based TaqIB genotyping (Clin Chem 2001)Clin Chem · May 2001 3
• Mapping a monoclonal antibody's CETP epitope explains why it blocks triglyceride but not cholesteryl ester transfer (J Lipid Res 1999)J Lipid Res · November 1999 3
• A new 1H NMR method tracks CETP-driven lipid transfer in lipoprotein mixtures without ultracentrifugation (NMR Biomed 1997)NMR Biomed · October 1997 3
• Recombinant cynomolgus monkey CETP is expressed and purified 176-fold from CHO cells for structural study (J Protein Chem 1995)J Protein Chem · February 1995 3
• Triazine-dye affinity chromatography purifies human CETP up to 100,000-fold from lipoprotein-depleted plasma (Protein Expr Purif 1994)Protein Expr Purif · June 1994 3